This User's Guide for Management and Mitigation of Per- and Polyfluoroalkyl Substances (PFAS) Leaching from Pavement outlines the decision-making process for preventing PFAS migration from aqueous film-forming foam impacted pavement into the environment. This User's Guide lays out the steps for managing PFAS-impacted pavement as well as additional work that needs to be completed to fully analyze the decisions made at each step in the process.