This is a User Guide developed under ESTCP project, “The VI Diagnosis Toolkit for Assessing Vapor Intrusion Pathways and Impacts in Neighborhoods Overlying Dissolved Chlorinated Solvent Plumes.” The VI Diagnosis Toolkit for Assessing Vapor Intrusion Pathways and Mitigating Impacts in Neighborhoods Overlying Dissolved Chlorinated Solvent Plumes is a set of tools that can be used selectively or in total in a sequence to assess volatile organic contaminant vapor intrusion impacts at one or more buildings overlying regional-scale chlorinated solvent-impacted dissolved groundwater plumes.